The Upper Mayrière Cave is an ornate cave near the Aveyron valley, in the commune of Bruniquel in Tarn-et-Garonne.

It consists of a large winding corridor 350 m long in which paintings from the Upper Paleolithic were discovered in 1952 by A. Jarlan. Located about fifty meters from the entrance, they were studied in 1976 by J. Clottes and R. Guicharnaud. They consist of two figures of bison following each other, on a panel 2 m long. On stylistic bases (frontal perspective of the horns, absence of anatomical details), these bison have been attributed to the Solutrean (style III of Leroi-Gourhan).

The paintings of the upper Mayrière cave were seriously altered in 1992 by a group of Girl Scouts of France, supervised by members of the Albigensian Caving Club, who undertook to clean the walls of the cavity. Two bison painted black were erased. "The traces of this cleaning, well marked, indicate a firm intention to remove all traces of paint, probably confused by the authors of the degradation, with graffiti made of "black smoke". This initiative earned the Girl Scouts of France the Ig-Nobel Prize in Archaeology in 1992.