Grotta Paglicci is a cave located in Paglicci (Rignano Garganico).

Deposit dating back to the Paleolithic (lower, middle, and upper) and rich in graffiti, rudimentary wall paintings, and handprints, more than 45,000 finds have been discovered in it, almost all preserved in the archives of the Archaeological Superintendence of Taranto and in the exhibition-museum of Rignano Garganico. Very similar to the Romanelli cave in paintings and graffiti, it is one of the most important archaeological sites in Italy.

Three burials and numerous individual human remains were also found in the cave, dating back to the Gravettian and Epigravettian periods. It is now agreed that the remains of Paglicci belong to Cro-Magnon man.[1] At the beginning of September 2020, the discovery in the cave of the oldest dog that lived in Italy dating back to a period between 14,000 and 20,000 years ago was announced.