Okladnikov Cave (Russian: пещера Окладникова) is a paleoanthropological site located in the foothills of the Altai Mountains in Soloneshensky District, Altai Krai in southern Siberia, Russia. The cave faces south and is located on a Devonian karst escarpment, lying about 14 meters (46 ft) above the left bank of the Sibiryachikha River valley below; the river itself is a tributary of the Anuy River.

Okladnikov Cave is one of the most extensively studied Paleolithic sites in the Altai-Sayan region. A rich Mousterian stone industry, dating to between 33,000 and 44,000 years ago, was discovered, as well as several highly fragmented hominin fossils. Along with a few other Neanderthal sites in the Altai-Sayan region, Okladnikov Cave contains fossil evidence for the most easterly confirmed site with Neanderthal presence.