Motsetsi Cave (also known as Motsetse) is a fossil-bearing breccia filled cavity located about 14 kilometres (8.7 mi) east of the well known South African hominid-bearing sites of Sterkfontein and Kromdraai and about 45 kilometres (28 mi) north-northwest of Johannesburg, South Africa. Motsetsi has been declared a South African National Heritage Site.

Motsetsi has been dated to 1.0 to 1.6 million years old based on the animals recovered.