The Trilobite cave is one of the cavities of the Arcy-sur-Cure caves site, between Auxerre and Avallon in the French department of Yonne, in the Bourgogne-Franche-Comté region (formerly Burgundy).

With six archaeological levels ranging from the Mousterian to the Neolithic, its stratigraphy is among the richest at the Arcy site. This is the first cave of the Yonne in which the Protosolutrean was discovered, the latter being unknown until then in the department.

The filling of its porch forms one of the richest stratigraphy of the Arcy site. It includes the 6 archaeological levels described by A. Parat, denoted C1 to C6, ranging from Mousterian in the Neolithic.

Unfortunately, the lack of proper care during past excavations irreparably destroyed the early Solutrean layer (~24,000 to 22,000 years BC), which is all the more regrettable since this cave is the first in the department in which this culture was found.