Fort Rock Cave was the site of the earliest evidence of human habitation in the US state of Oregon before the excavation of Paisley Caves. Fort Rock Cave featured numerous well-preserved sagebrush sandals, ranging from 9,000 to 13,000 years old. The cave is located approximately 1.5 miles (2.4 km) west of Fort Rock near Fort Rock State Natural Area in Lake County. Fort Rock Cave was declared a National Historic Landmark in 1961, and added to the National Register of Historic Places in 1966.

The cave was found on Reub Long's ranch. It was formerly known as Menkenmaier Cave and Cow Cave.