Font-de-Gaume is a cave near Les Eyzies-de-Tayac-Sireuil in the Dordogne départment of south-west France. The cave contains prehistoric polychrome cave paintings and engravings dating to the Magdalenian period. Discovered in 1901, more than 200 images have been identified in Font-de-Gaume. Along with other nearby prehistoric archeological sites, Font-de-Gaume was inscribed on the UNESCO World Heritage List in 1979 as the Prehistoric Sites and Decorated Caves of the Vézère Valley.

Prehistoric people living in the Dordogne Valley first settled in the mouth of Font-de-Gaume around 25,000 BC. The cave mouth was inhabited at least sporadically for the next several thousand years. However, after the original prehistoric inhabitants left, the cave was forgotten until the nineteenth century when local people again began to visit the cave. The paintings date from around 17,000 BC, during the Magdalenian period. Many of the cave's paintings have been discovered in recent decades. The cave's most famous painting, a frieze of five bison, was discovered accidentally in 1966 while scientists were cleaning the cave.