Dust Cave is a Paleoindian archaeology site located in northern Alabama. It is in the Highland Rim in the limestone bluffs that overlook Coffee Slough, a tributary of the Tennessee River. The site was occupied during the Pleistocene and early Holocene eras. 1LU496, another name for Dust Cave, was occupied seasonally for 7,000 years. The cave was discovered in 1984 by Dr. Richard Cobb and initially excavated in 1989 under Dr. Boyce Driskell from the University of Alabama.

Other major Paleoindian sites in northern Alabama include Stanfield-Worley, Mulberry Creek, the Quad site and Heaven's Half Acre.

The first lithic analysis was conducted on 130 chipped stone tools from test unit F. These stone tools came from one of the units that had been excavated down to bedrock. This unit was chosen for that reason and because it had representation from all of the five cultural components. Zones T and U represent the Paleoindian period. A reworked Cumberland point, Quad, Beaver Lake, Hardaway Side-Notched, and Dalton projectile points were found in these two units. These are all Paleoindian projectile points and date in between 12,650 and 11,200 cal B.P.