The Brillenhöhle (German: Brillenhöhle, literally spectacles cave) is a cave ruin, located 16 km (9.94 mi) west of Ulm on the Swabian Alb in south-western Germany, where archaeological excavations have documented human habitation since as early as 30,000 years ago. Excavated by Gustav Riek from 1955 to 1963, the cave's Upper Paleolithic layers contain a sequence of Aurignacian, Gravettian, and Magdalenian artifacts. In 1956 the first human fossils were discovered within a fireplace in the center of the cave, a discovery which made important contributions to the foundational understanding of the Magdalenian culture of central Europe.

The remains of at least four distinct individuals, all associated with the Magdalenian, were discovered at Brillenhöhle. In 2016, researchers successfully extracted the DNA from the parietal bone of one of the individuals. The bone fragment was directly dated to around 15,120-14,440 BP. The individual in question was found to belong to mtDNA Haplogroup U8a. The Brillenhöhle individual was found to be genetically closest to other ancient samples from the Magdalenian, showing closest genetic affinity for other samples taken from the Swabian Jura, such as Hohle Fels, while also showing a genetic affinity for another Magdalenian sample, taken from the Red Lady of El Mirón, as well as a sample from the Aurignacian, GoyetQ116-1, taken from Goyet Caves.