The Apidima Cave (Greek: Σπήλαιο Απήδημα, Spilaio Apidima) is a complex of five caves four small caves located on the western shore of Mani Peninsula in Southern Greece. A systematic investigation of the cave has yielded Neanderthal and Homo sapiens fossils from the Palaeolithic era.

One skull fossil, given the name Apidima 1, shows a mixture of modern human and primitive features and has been dated to be more than 210,000 years old, older than a Neanderthal skull ("Apidima 2") found at the cave, which per some interpretations makes Apidima 1 the oldest proof of Homo sapiens living outside Africa, the second oldest being the maxilla from Misliya cave, Mount Carmel, Israel, with a maximum age of about 190,000 years ago. Apidima 1 is more than 150,000 years older than previous H. sapiens finds in Europe.